NCIt definition : An orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive
and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations
via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation
of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention
of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually
lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible
tumor cells. This agent may act synergistically with other chemotherapeutic agents.
PKC, a family of serine/threonine protein kinases overexpressed in certain types of
cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and
the activation and survival of lymphocytes.;
UNII : 7I279E1NZ8;
InChIKey : OAVGBZOFDPFGPJ-UHFFFAOYSA-N;
CAS number : 425637-18-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 425637-18-9
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