Preferred Label : TRK Inhibitor AZD6918;
NCIt definition : An orally available liquid suspension containing the tropomyosin receptor kinase (Trk)
inhibitor AZD6918 with potential antineoplastic activity. AZD6918 binds to Trk, thereby
preventing neurotrophin-Trk interaction and Trk activation, and may eventually result
in cell cycle arrest and apoptosis of tumor cells that express Trk. Trk, a receptor
tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell
types and plays an important role in tumor cell growth and survival.;
Molecule name : AZD6918;
NCI Metathesaurus CUI : CL388367;
Origin ID : C80491;
UMLS CUI : C2825220;
Semantic type(s)
- concept_is_in_subset
