Preferred Label : Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7;
NCIt synonyms : Lip and Oral Cavity Carcinoma Stage IV; Stage IV Lip and Oral Cavity Cancer v7; Lip and Oral Cavity Cancer Stage IV; Stage IV Lip and Oral Cavity Cancer v6; Stage IV Lip and Oral Cavity Carcinoma;
NCIt related terms : Stage IV Lip and Oral Cavity Cancer;
NCIt definition : Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3,
N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N,
M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor
of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent
structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue,
maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates,
or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral
lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple
ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral
or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis
in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.
N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest
dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than
6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest
dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.);
Alternative definition : NCI-GLOSS: Stage IV is divided into stages IVA, IVB, and IVC. In stage IVA, (1) the
tumor has spread through tissue in the lip or oral cavity into nearby tissue and/or
bone (jaw, tongue, floor of mouth, maxillary sinus, or skin of chin or nose); cancer
may have spread to one lymph node that is 3 centimeters or smaller, on the same side
of the neck as the tumor; or (2) the tumor is any size or has spread through tissue
in the lip or oral cavity into nearby tissue and/or bone (jaw, tongue, floor of mouth,
maxillary sinus, or skin of chin or nose). Cancer has spread to one lymph node on
the same side of the neck as the tumor and the lymph node is larger than 3 centimeters
but not larger than 6 centimeters, or to more than one lymph node on the same side
of the neck as the tumor and the lymph nodes are not larger than 6 centimeters, or
to lymph nodes on the opposite side of the neck as the tumor or on both sides of the
neck, and the lymph nodes are not larger than 6 centimeters. In stage IVB, (1) the
tumor may be any size and has spread to one or more lymph nodes that are larger than
6 centimeters; or (2) the tumor has spread further into the muscles or bones in the
oral cavity, or to the base of the skull and/or the carotid artery. Cancer may have
spread to one or more lymph nodes anywhere in the neck. In stage IVC, the tumor has
spread beyond the lip or oral cavity to distant parts of the body, such as the lungs.
The tumor may be any size and may have spread to lymph nodes.;
Neoplastic status : Malignant;
Codes from synonyms : CDR0000045280;
Origin ID : C8036;
UMLS CUI : C4520747;
Automatic exact mappings (from CISMeF team)
- Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
