Proxyphylline - CISMeF

Preferred Label : Proxyphylline;

NCIt synonyms : 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; 2-Hydroxypropyl-7-theophylline; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-; Beta-Oxypropyltheophyllin;

NCIt definition : A methylxanthine and derivative of theophylline. Proxyphylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Proxyphylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.;

UNII : 13G1DMN4P0;

InChIKey : KYHQZNGJUGFTGR-UHFFFAOYSA-N;

CAS number : 603-00-9;

Drug name : Theon; Brontyl;

Chemical formula : C10H14N4O3;

NSC code : 163343;

Details

Origin ID

C80339;

UMLS CUI

C0072511;

Currated CISMeF NLP mapping
- Proxyphylline [ICD-11 Extension code]
- proxyphylline [Substance BNPC]
- proxyphylline [MeSH concept]
- proxyphylline [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Proxyphylline [ICD-11 Extension code]
- proxyphylline [ATC Code]
- proxyphylline [Substance BNPC]
- proxyphylline [MeSH concept]
- proxyphylline [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- proxyphylline [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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