Progressive Hairy Cell Leukemia Initial Treatment

Preferred Label : Progressive Hairy Cell Leukemia Initial Treatment;

NCIt synonyms : Progressive Hairy Cell Leukemia, Initial Treatment;

NCIt definition : A hairy cell leukemia requiring initial treatment because of the presence of signs of progression. Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications. Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.;

Neoplastic status : Malignant;

Details

Origin ID

C8029;

UMLS CUI

C0279779;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Intervention Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Hairy Cell [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- BRAF V600E Mutation Present [NCIt concept]
- Fried-Egg Appearance of the Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Progressive Clinical Course [NCIt concept]
- Reticulin Fibrosis of the Bone Marrow [NCIt concept]
- Splenomegaly [NCIt concept]
- Tartrate Resistant Acid Phosphatase Positive Cells Present [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- BRAF Gene [NCIt concept]
disease_may_have_associated_disease
- Opportunistic Infection [NCIt concept]
- Vasculitis [NCIt concept]
disease_may_have_molecular_abnormality
- CCND1 Protein Overexpression [NCIt concept]

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