Preferred Label : Zopiclone;
NCIt synonyms : ( -)-Zopiclone; 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl
Ester; 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine;
NCIt related terms : Zimovane; Imovane;
NCIt definition : The racemic form of a nonbenzodiazepine, cyclopyrrolone with hypnotic and sedative
activity and without significant anxiolytic activity. Although the exact mechanism
of action remains to be fully elucidated, zopiclone is able to bind to and activate
the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine
GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous
system (CNS). This leads to the opening of chloride channels, causing hyperpolarization,
inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This
eventually leads to a hypnotic effect and allows for an induction of sleep.;
UNII : 03A5ORL08Q;
InChIKey : GBBSUAFBMRNDJC-UHFFFAOYSA-N;
CAS number : 43200-80-2;
Drug name : Amoban; Zimovane; Imovane;
Molecule name : RP 27267;
Chemical formula : C17H17ClN6O3;
ChEBI ID : CHEBI:32315;
Origin ID : C80279;
UMLS CUI : C0078847;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
