Fentanyl Matrix Transdermal Patch

Preferred Label : Fentanyl Matrix Transdermal Patch;

NCIt synonyms : Fentanyl Matrix Transdermal Delivery System;

NCIt definition : A transdermal formulation containing the synthetic phenylpiperidine opioid agonist fentanyl, with analgesic activity. Upon topical administration, fentanyl diffuses from the transdermal patch through the skin, is transported via the systemic circulation, and selectively binds to the mu-receptor in the central nervous system (CNS), mimicking the effects of endogenous opiates. Stimulation of the mu-receptor inhibits adenyl cyclase activity, induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels, and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability; in addition, neuronal release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline may decrease.;

Drug name : Durogesic DTrans;

NCI Metathesaurus CUI : CL388406;

Details

Origin ID

C80067;

UMLS CUI

C2700171;

Automatic exact mappings (from CISMeF team)
- Fentanyl 100micrograms/hour patch (product) [Inactive SNOMED CT concept]
- Fentanyl 25micrograms/hour patch (product) [Inactive SNOMED CT concept]
- Fentanyl 50micrograms/hour patch (product) [Inactive SNOMED CT concept]
- Fentanyl 75micrograms/hour patch (product) [Inactive SNOMED CT concept]
- Product containing precisely fentanyl 12 microgram/1 hour prolonged-release transdermal patch (clinical drug) [SNOMED CT concept]
Semantic type(s)
- Clinical Drug [UMLS semantic type]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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