NCIt definition : A synthetic analogue of the lipid A portion of the endotoxin lipopolysaccharide (LPS)
with potential immunomodulating activity. Eritoran binds to a receptor complex composed
of toll-like receptor 4 (TLR4), CD14 and MD2 (MD-2, LY96) that is present on most
cells of the immune system, inhibiting the activation of the receptor complex by LPS,
which may result in the inhibition of pro-inflammatory cytokine secretion and a potentially
fatal systemic inflammatory response syndrome (SIRS). LPS is found in the outer membrane
of Gram-negative bacteria and binds to the TLR4/CD14/MD2 receptor complex of immune
cells, including macrophages, resulting in the release of pro-inflammatory cytokines.;
UNII : 551541VI0Y;
InChIKey : BPSMYQFMCXXNPC-MFCPCZTFSA-N;
CAS number : 185955-34-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 185955-34-4
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