" /> Eritoran - CISMeF





Preferred Label : Eritoran;

NCIt definition : A synthetic analogue of the lipid A portion of the endotoxin lipopolysaccharide (LPS) with potential immunomodulating activity. Eritoran binds to a receptor complex composed of toll-like receptor 4 (TLR4), CD14 and MD2 (MD-2, LY96) that is present on most cells of the immune system, inhibiting the activation of the receptor complex by LPS, which may result in the inhibition of pro-inflammatory cytokine secretion and a potentially fatal systemic inflammatory response syndrome (SIRS). LPS is found in the outer membrane of Gram-negative bacteria and binds to the TLR4/CD14/MD2 receptor complex of immune cells, including macrophages, resulting in the release of pro-inflammatory cytokines.;

UNII : 551541VI0Y;

InChIKey : BPSMYQFMCXXNPC-MFCPCZTFSA-N;

CAS number : 185955-34-4;

Chemical formula : C66H126N2O19P2;

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Keyword's position in hierarchy(ies) : arborescence

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28/05/2025


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