Preferred Label : Cyclosporine Ophthalmic Emulsion;
NCIt definition : An topical ophthalmic formulation containing cyclosporine, an undecapeptide produced
by the fungus Beauveria nivea, with immunosuppressant and anti-inflammatory activities.
The exact therapeutic mechanism of action of cyclosporine is not known but may involve
binding to the cellular protein cytophilin, resulting in inhibition of the enzyme
calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent
lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially
inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine
production and release.;
Drug name : Restasis;
Origin ID : C80051;
UMLS CUI : C2699534;
Semantic type(s)
- concept_is_in_subset
