Preferred Label : Caricotamide/Tretazicar;
NCIt synonyms : Caricotamide Tretazicar;
NCIt definition : A combination therapy consisting of the prodrug tretazicar and the enzyme co-substrate
caricotamide with potential antineoplastic activity. In the presence of separately
and simultaneously administered caricotamide, tretazicar is converted to the short-lived
cytotoxic DNA cross-linking agent dinitrobenzamide by NAD(P)H quinine oxidoreductase
2 (NQO2), resulting in the inhibition of DNA replication and the induction of apoptosis.
NQO2 has been found to be elevated in certain cancers such as hepatocellular carcinoma
(HCC).;
Drug name : Prolarix;
Molecule name : EP-0152R/CB1954;
NCI Metathesaurus CUI : CL388385;
Origin ID : C80048;
UMLS CUI : C2699001;
Semantic type(s)
- concept_is_in_subset
