NCIt definition : A humanized monoclonal antibody directed against the cell surface oncofetal protein
glypican-3 (GPC3) with potential antineoplastic activity. Anti-GPC3 monoclonal antibody
GC33 binds to GPC3 and triggers a host immune response against GPC3-expressing tumor
cells, which may result in tumor cell death. GPC3, a heparin sulfate proteoglycan,
is frequently upregulated in hepatocellular carcinoma and mesoderm-derived organs
such as the liver, lungs, and kidney.;
UNII : U9I0PLD4HT;
CAS number : 1365267-33-9;
Molecule name : GC-33; RO 5137382; RO-5137382; RG 7686;