Combretastatin

Preferred Label : Combretastatin;

NCIt synonyms : 3-Hydroxy-4-methoxy-alpha-(3,4,5-trimethoxyphenyl)benzeneethanol;

NCIt related terms : Combretastatin, ( -);

NCIt definition : A stilbenoid phenol, originally isolated from the bark of the African bush willow tree Combretum caffrum, with vascular disrupting and antineoplastic activities. Combretastatin targets and binds to the colchicine-binding site of tubulin, thereby impairs the polymerization of tubulin dimers and prevents the formation of microtubules in the endothelial cells of tumor. As a result, this may eventually lead to a destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis.;

UNII : 7O62J06F18;

CAS number : 82855-09-2;

NSC code : 348103;

Codes from synonyms : NSC0600168; NSC03481;

Details

Origin ID

C80014;

UMLS CUI

C0056152;

Currated CISMeF NLP mapping
- combretastatin [MeSH concept]
- combretastatin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- combretastatin [MeSH concept]
- combretastatin [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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