NCIt definition : A stilbenoid phenol, originally isolated from the bark of the African bush willow
tree Combretum caffrum, with vascular disrupting and antineoplastic activities. Combretastatin
targets and binds to the colchicine-binding site of tubulin, thereby impairs the polymerization
of tubulin dimers and prevents the formation of microtubules in the endothelial cells
of tumor. As a result, this may eventually lead to a destruction of the tumor vasculature,
disruption of tumor blood flow and tumor cell necrosis.;
UNII : 7O62J06F18;
CAS number : 82855-09-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 82855-09-2
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