Preferred Label : Alvespimycin;
Obsolete resource : true;
NCIt synonyms : Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-; 17-DMAG;
NCIt definition : An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin
binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding
of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation
and depletion of its client proteins such as kinases and transcription factors involved
with cell cycle regulation and signal transduction.;
NCIt note : See ' 17-Dimethylaminoethylamino 17-Demethoxygeldanamycin';
Concept status : Retired_Concept;
UNII : 001L2FE0M3;
InChIKey : KUFRQPKVAWMTJO-LMZWQJSESA-N;
CAS number : 467214-20-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 467214-20-6
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G-SRS /a ;
Chemical formula : C32H48N4O8;
NCI Metathesaurus CUI : CL388611;
Origin ID : C79937;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
