Preferred Label : Caricotamide;
NCIt synonyms : 1-(2-Amino-2-oxoethyl)-1,4-dihydropyridine-3-carboxamide;
NCIt definition : A synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase
2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered
simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional
alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA
interstrand cross-links, resulting in the inhibition of DNA replication and the induction
of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular
carcinoma (HCC), colorectal and ovarian cancers.;
UNII : MC09H30MFS;
InChIKey : WEJRSYKFMCUCRQ-UHFFFAOYSA-N;
CAS number : 64881-21-6;
Chemical formula : C8H11N3O2;
PubMed : 18062662;
Origin ID : C79915;
UMLS CUI : C2699000;
Semantic type(s)
- concept_is_in_subset
