Preferred Label : PPE-Expressing Replication-Defective HSV-1 Vector NP2;
NCIt synonyms : Preproenkephalin-Expressing Replication-Defective Herpes Simplex Virus-1 Vector NP2; PPE-Expressing Nonreplicating HSV-1-Based Vector NP2;
NCIt definition : A replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector
expressing the human preproenkephalin A (PPE) gene with potential antinociceptive
activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1
vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion
(DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with
high efficiency, delivering the engineered PPE gene; transduced neurons then express
the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic
cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met-
and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the
inhibition of nociceptive neurotransmission.;
Molecule name : NP2;
NCI Metathesaurus CUI : CL388508;
Origin ID : C79845;
UMLS CUI : C2698699;
Semantic type(s)
- concept_is_in_subset
