Preferred Label : Bizaxofusp;
NCIt synonyms : IL4-PE; Interleukin-4 Fusion Toxin; IL-4 Fusion Toxin; IL-4 PE38KDEL Immunotoxin; Interleukin-4 Pseudomonas Exotoxin; Interleukin-4 PE38kdel Immunotoxin; IL4-Pseudomonas Exotoxin Fusion Protein MDNA55;
NCIt related terms : NBI-3001; interleukin-4 PE38KDEL cytotoxin;
NCIt definition : A fusion protein consisting of the cytokine interleukin-4 (IL-4) linked to a truncated
form of Pseudomonas exotoxin with potential antineoplastic activity. Upon specific,
high-affinity binding to IL-4 receptors located on the tumor cell surface., bizaxofusp
is internalized; the exotoxin moiety then binds to translation elongation factor 2
(EF-2), which may result in ADP ribosylation, deactivation of EF-2, inhibition of
protein synthesis, and tumor cell apoptosis. The Pseudomonas exotoxin moiety of this
agent has been engineered to reduce non-specific binding to cells expressing its receptor,
the multiligand cell surface receptor alpha 2-macroglobulin receptor/low-density lipoprotein
receptor-related protein (alpha 2MR/LRP). IL-4R is a type I transmembrane protein
that binds IL-4 and IL-13 and may be overexpressed by cancers such as renal cell carcinoma
and glioma.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is made by combining
interleukin-4 with a bacterial toxin. Interleukin-4 PE38KDEL immunotoxin is a type
of recombinant chimeric protein.;
UNII : FRY3MOL2QU;
CAS number : 1236019-35-4;
Drug name : INxin;
Molecule name : PRX-321; MDNA55; NBI-3001;
NCI Metathesaurus CUI : CL388450;
Codes from synonyms : CDR0000373995; CDR0000045550; CDR0000046697;
Origin ID : C79843;
UMLS CUI : C5708874;
Semantic type(s)
- concept_is_in_subset
