Preferred Label : Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes;
NCIt synonyms : Anti-CEA TCR Retroviral Vector-Transduced Autologous PBLs; Anti-CEA TCR-Gene Engineered Autologous Lymphocytes;
NCIt definition : Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral
vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific
for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic
activities. After transduction, expansion in culture, and reintroduction into the
patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to
tumor cells expressing CEA, which may result in cytokine expression, activation and
proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against
CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed
by a variety of cancer cell types, including those of the gastrointestinal tract,
lung, and breast.;
NCI Metathesaurus CUI : CL388449;
Origin ID : C79842;
UMLS CUI : C2698131;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
