Preferred Label : Talmapimod;
NCIt synonyms : 1H-indole-3-acetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-
piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-; 2-[6-Chloro-5-[[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl]-1-
methyl-1H-indol-3-yl]-N,N-dimethyl-2-oxoacetamide;
NCIt definition : An orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK)
inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities.
Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which
may result in the induction of tumor cell apoptosis, the inhibition of tumor cell
proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance
proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase
involved in a MAPK signaling cascade that controls cellular responses to various environmental
stresses, cytokines, and endotoxins.;
UNII : B1E00KQ6NT;
InChIKey : ZMELOYOKMZBMRB-DLBZAZTESA-N;
CAS number : 309913-83-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 309913-83-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : SCIO 469;
Chemical formula : C27H30ClFN4O3;
Origin ID : C79841;
UMLS CUI : C2699882;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
