Preferred Label : Olvimulogene Nanivacirepvec;
NCIt synonyms : Light-Emitting Oncolytic Vaccinia Virus GL-ONC1;
NCIt definition : An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein
Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent
and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia
virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor
vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis
and the release of mature viral particles into the tumor microenvironment. Released
viral particles may then infect and destroy neighboring tumor cells. In addition,
the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream
may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against
the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring
of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence
imaging and fluorescence imaging techniques.;
UNII : CF19SF72O5;
CAS number : 1473430-36-2;
Drug name : Olvi-Vec;
Molecule name : GLV-1h68; GL-ONC1;
NCI Metathesaurus CUI : CL388438;
Origin ID : C79833;
UMLS CUI : C5421245;
Semantic type(s)
- concept_is_in_subset
