Preferred Label : ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine;
NCIt synonyms : ALVAC 2 NY-ESO-1 M TRICOM Vaccine;
NCIt definition : A cancer vaccine consisting of a replication-defective recombinant canarypox virus
[ALVAC(2)] encoding the cancer-testis antigen NY-ESO and the TRIad of COstimulatory
Molecules (B7-1, ICAM-1 and LFA-3; also called TRICOM), with potential immunostimulatory
and antineoplastic activities. Upon administration, ALVAC(2)/NY-ESO (M)/TRICOM vaccine
may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response
against NY-ESO-expressing cancer cells, which may result in the inhibition of tumor
cell proliferation. NY-ESO-1, a tumor associated antigen (TAA), is found in normal
testis and on the surface of various tumor cells, including bladder, breast, hepatocellular,
melanoma, and prostate tumor cells. TRICOM may enhance antigen presentation and activate
cytotoxic T-cells. In addition, ALVAC(2) encodes the vaccinia virus (vv) E3L ad K3L
genes, which may potentiate the translation of the NY-ESO and TRICOM genes.;
Molecule name : vCP2292;
NCI Metathesaurus CUI : CL388436;
Origin ID : C79832;
UMLS CUI : C2698716;
- Semantic type(s)
- concept_is_in_subset
- has_target