NCIt definition : The hydrate of tatirelin, a thyrotropin releasing hormone (TRH) analogue with potential
neuroprotective, analgesic and central nervous system-stimulating (CNS)/analeptic
activities. Taltirelin mimics the physiological actions of TRH on the CNS while exerting
a minimal effect on the release of thyrotrophin (TSH) from the anterior lobe of the
pituitary. Like TRH, the mechanism of action of this agent in the CNS has not been
fully elucidated mechanism, but may involve various cerebral monoamine pathways. Compared
to TRH, taltirelin has a much longer half-life and duration of effects.;