Irosustat - CISMeF

Preferred Label : Irosustat;

NCIt synonyms : Steroid Sulfatase Inhibitor BN 83495; 667 Coumate;

NCIt definition : Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively.;

UNII : 366037O6O7;

InChIKey : DSLPMJSGSBLWRE-UHFFFAOYSA-N;

CAS number : 288628-05-7;

Molecule name : STX 64; BN83495;

Chemical formula : C14H15NO5S;

Details

Origin ID

C79827;

UMLS CUI

C3853843;

Automatic exact mappings (from CISMeF team)
- 667 coumate [MeSH concept]
- irosustat [MeSH Supplementary Concept]
- irosustat [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- irosustat [MeSH concept]
- irosustat [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Steryl-Sulfatase [NCIt concept]

Keyword's position in hierarchy(ies) :

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