" /> Namodenoson - CISMeF





Preferred Label : Namodenoson;

NCIt synonyms : A3AdR Agonist CF102; Adenosine Receptor A3 Agonist CF102; 2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide; C-Ibza-MU; 2-Cl-IB-MECA; Adenosine A3 Receptor Agonist CF102; beta-D-Ribofuranuronamide, 1-(2-Chloro-6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-1-deoxy-N-methyl-;

NCIt definition : An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.;

UNII : Z07JR07J6C;

InChIKey : IPSYPUKKXMNCNQ-PFHKOEEOSA-N;

CAS number : 163042-96-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 163042-96-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CF102;

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12/05/2024


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