Preferred Label : Ad5-CMV-NIS;
NCIt definition : A recombinant type 5 adenovirus (Ad5), encoding the gene for the human sodium-iodide
symporter (NIS) linked to the cytomegalovirus (CMV) promoter, with potential gene
transfection activity. Upon intratumoral injection, Ad5-CMV-NIS is taken up by tumor
cells, resulting in the cellular expression of NIS. Subsequently, orally administered
iodine 131 is taken up by NIS-expressing tumor cells, which may result in the selective
accumulation of a cytotoxic dose of beta and gamma radiation in non-thyroidal tumor
cells, sparing adjacent normal tissue. NIS, an intrinsic membrane glycoprotein, is
an ion pump that actively transports iodide into cells which concentrate iodine; in
addition to thyroid epithelial cells, it is found in non-thyroidal tissues including
the salivary glands, the gastric mucosa, and lactating mammary glands.;
NCI Metathesaurus CUI : CL388415;
Origin ID : C79800;
UMLS CUI : C2700161;
Semantic type(s)
- concept_is_in_subset
