Childhood Acute Megakaryoblastic Leukemia

Preferred Label : Childhood Acute Megakaryoblastic Leukemia;

NCIt synonyms : Pediatric Acute M7 Leukemia; Childhood Acute M7 Leukemia; Pediatric Acute Megakaryoblastic Leukemia; M7 Pediatric Acute Megakaryocytic Leukemia; Childhood Acute Megakaryocytic Leukemia (M7); M7 Childhood Acute Megakaryocytic Leukemia; Childhood Acute Megakaryocytic Leukemia; Pediatric Acute Megakaryocytic Leukemia;

NCIt related terms : Acute Megakaryoblastic Leukemia; Childhood AMKL;

NCIt definition : An acute megakaryoblastic leukemia occurring in children.;

Alternative definition : NICHD: A subtype of acute myeloid leukemia involving the megakaryocytic line. The majority of the cases are associated with t(1;22)(p13;q13). The following recurrent genetic abnormalities have been reported with pediatric AMKL: NUP98/JARID1A, RBM15/MKL, and CBFA2T3/GLIS2. GATA1 mutations are not observed in non-Trisomy 21 (Down syndrome) children with AMKL.;

Neoplastic status : Malignant;

Details

Origin ID

C7972;

UMLS CUI

C0279650;

Automatic exact mappings (from CISMeF team)
- Acute megakaryoblastic leukemia [MedDRA LLT]
- Acute megakaryoblastic leukemia [ICD-O code]
- Acute megakaryoblastic leukemia [ICD-10 Sub-category]
- Acute megakaryoblastic leukemia (disorder) [SNOMED CT concept]
- Acute megakaryoblastic leukemia (morphologic abnormality) [SNOMED CT concept]
- acute megakaryoblastic leukemia [SNOMED Notion]
- acute megakaryocytic leukemia [DO Concept]
- leukemia, megakaryoblastic, acute [MeSH Descriptor]
- leukemia, megakaryoblastic, acute [MeSH concept]
Disease excludes abnormal cell
- Neoplastic Erythroblast [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Thrombocytopenia [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
Validated automatic mappings to NTBT
- Acute megakaryoblastic leukemia [ORDO Disease]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Bone Marrow Dysplasia Present in 50 Percent or More of the Cells of Two Cell Lines [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Megakaryoblast [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 20 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Childhood Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Megakaryoblasts 50 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Abnormal Platelet [NCIt concept]
- Dysplastic Neutrophil [NCIt concept]
- Micromegakaryocyte [NCIt concept]
disease_may_have_associated_disease
- Mediastinal Germ Cell Tumor [NCIt concept]

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