Ammonia N-13 - CISMeF

Preferred Label : Ammonia N-13;

NCIt synonyms : Ammonia-(sup 13)N; Ammonia N 13; 13NH3; 13N-labeled Ammonia;

NCIt definition : A radiopharmaceutical composed of ammonia labeled with the radioisotope nitrogen N 13 that can be used, during positron emission tomography (PET), as a blood flow imaging agent and potentially as a tumor imaging agent. Upon intravenous administration, ammonia N 13 distributes to various organs in the body, such as the myocardium, liver, kidneys and brain. This agent is taken up by cells and is retained following conversion to glutamine N 13 by glutamine synthetase (GS). Upon PET, organ perfusion and the presence of cancer cells can be assessed. GS, an enzyme that catalyzes the synthesis of glutamine from glutamate and ammonia, is overexpressed in a variety of cancers and plays a key role in cancer cell proliferation.;

UNII : 9OQO0E343Z;

InChIKey : QGZKDVFQNNGYKY-BJUDXGSMSA-N;

CAS number : 34819-78-8;

Chemical formula : H3N;

Details

Origin ID

C79714;

UMLS CUI

C1998431;

Currated CISMeF NLP mapping
- Ammonia (13-N) (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing ammonia (13-N) (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ammonia (13-N) (substance) [SNOMED CT concept]
- Product containing ammonia (13-N) (medicinal product) [SNOMED CT concept]
- ammonia (13N) [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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