Cefazaflur - CISMeF

Preferred Label : Cefazaflur;

NCIt synonyms : (6R,7R)-3-(((1-Methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-7-(2-((trifluormethyl)thio)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure;

NCIt definition : A semisynthetic first-generation cephalosporin with antibacterial activity. Cefazaflur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.;

UNII : 97I0692RNT;

InChIKey : HGXLJRWXCXSEJO-GMSGAONNSA-N;

CAS number : 58665-96-6;

Chemical formula : C13H13F3N6O4S3;

Details

Origin ID

C79419;

UMLS CUI

C0054998;

Currated CISMeF NLP mapping
- Cefazaflur [SMS substance]
- cefazaflur [MeSH concept]
- cefazaflur [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cefazaflur [MeSH concept]
- cefazaflur [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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