Preferred Label : Quercetin;
NCIt synonyms : C.I. Natural Yellow 10; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one; 3,3',4',5,7-Pentahydroxyflavone;
NCIt related terms : 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one;
NCIt definition : A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous
in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative
effects resulting from the modulation of either EGFR or estrogen-receptor mediated
signal transduction pathways. Although the mechanism of action of action is not fully
known, the following effects have been described with this agent in vitro: decreased
expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest
at the G1 phase and inhibition of heat shock protein synthesis. This compound also
demonstrates synergy and reversal of the multidrug resistance phenotype, when combined
with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and
anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase
pathways, thereby preventing the production of pro-inflammatory mediators.;
Alternative definition : CRCH: A kaempferol with a hydroxyl group at C-3'.;
UNII : 9IKM0I5T1E;
InChIKey : REFJWTPEDVJJIY-UHFFFAOYSA-N;
CAS number : 117-39-5;
Unit used : mg;
Chemical formula : C15H10O7;
NSC code : 9219;
ChEBI ID : CHEBI:16243;
Codes from synonyms : NSC0009219; 00221;
Origin ID : C792;
UMLS CUI : C0034392;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- morin [MeSH Supplementary Concept]
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
