Thyroid Gland Anaplastic Carcinoma, Osteoclastic Variant

Preferred Label : Thyroid Gland Anaplastic Carcinoma, Osteoclastic Variant;

NCIt synonyms : Anaplastic Giant Cell Thyroid Carcinoma;

NCIt definition : An extremely rare morphologic variant of anaplastic carcinoma of the thyroid gland, characterized by the presence of large numbers of non-neoplastic, osteoclast-like giant cells.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL563151;

Details

Origin ID

C7906;

UMLS CUI

C4745369;

Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Coagulative Necrosis [NCIt concept]
- Dysphagia [NCIt concept]
- Dyspnea [NCIt concept]
- Hoarseness [NCIt concept]
- Vocal Cord Paralysis [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
- Thyroid Gland [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Glandular Differentiation [NCIt concept]
- Squamous Differentiation [NCIt concept]
disease_has_abnormal_cell
- Anaplastic Carcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Epithelial Large Cell [NCIt concept]
- Malignant Epithelial Spindle Cell [NCIt concept]
- Malignant Epithelioid Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Non-Neoplastic Osteoclast-Like Giant Cell [NCIt concept]
- Osteoclast-Like Giant Cell [NCIt concept]
- Undifferentiated Carcinoma Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Rapidly Enlarging Mass [NCIt concept]
- Undifferentiated Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Thyroid Gland Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
- Thyroid Gland [NCIt concept]
disease_may_have_molecular_abnormality
- BRAF NP_004324.2:p.V600E [NCIt concept]
- HRAS Gene Mutation [NCIt concept]
- KRAS Gene Mutation [NCIt concept]
- NRAS Gene Mutation [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]
- TERT Promoter Mutation [NCIt concept]
- TP53 Gene Mutation [NCIt concept]

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