Indatuximab Ravtansine

Preferred Label : Indatuximab Ravtansine;

NCIt synonyms : Maytansinoid-Conjugated Anti-Myeloma Monoclonal Antibody BT062; Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062;

NCIt definition : An immunoconjugate consisting of a monoclonal antibody directed against syndecan-1 (CD138) covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Upon administration, indatuximab ravtansine binds to syndecan-1-expressing tumor cells; upon internalization the DM4 moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion.;

UNII : XGL4M23834;

CAS number : 1238517-16-2;

Molecule name : BT-062;

NCI Metathesaurus CUI : CL387726;

Details

Origin ID

C78840;

UMLS CUI

C4547156;

Currated CISMeF NLP mapping
- indatuximab ravtansine [MeSH Supplementary Concept]
- indatuximab ravtansine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- indatuximab ravtansine [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Syndecan-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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