Preferred Label : Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388;
NCIt synonyms : Anti-Integrin Immunotoxin IMGN388;
NCIt definition : An immunoconjugate consisting of an anti-integrin monoclonal antibody covalently attached
to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with
potential antineoplastic activity. Integrin-targeted immunoconjugate IMGN388 binds
to tumor cell surface integrins; upon internalization, the DM4 moiety is released
from the immunoconjugate, binding to tubulin and disrupting microtubule assembly/disassembly
dynamics, which may result in inhibition of cell division and cell growth of integrin-expressing
tumor cells. Integrins, a class of transmembrane cell surface receptors, link the
extracellular matrix (ECM) to intracellular signaling pathways that control cell proliferation
and differentiation.;
Molecule name : IMGN388;
NCI Metathesaurus CUI : CL387679;
Origin ID : C78839;
UMLS CUI : C2703134;
Semantic type(s)
- concept_is_in_subset
