Imgatuzumab - CISMeF

Preferred Label : Imgatuzumab;

NCIt synonyms : Anti-Epidermal Growth Factor Receptor Monoclonal Antibody RO5083945; Anti-EGFR Monoclonal Antibody RO5083945;

NCIt definition : A glycoengineered monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Imgatuzumab binds to the extracellular domain of EGFR, preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition of downstream ERK and JNK signaling pathways and so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of various solid tumor cell types.;

UNII : V77J4WJF9Z;

CAS number : 959963-46-3;

Molecule name : GA-201; RG-7160; RG 7160;

NCI Metathesaurus CUI : CL387675;

Details

Origin ID

C78838;

UMLS CUI

C5139897;

Currated CISMeF NLP mapping
- imgatuzumab [MeSH concept]
- imgatuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- imgatuzumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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