Preferred Label : LV.IL-2/B7.1-Transduced AML Blast Vaccine RFUSIN2-AML1;
NCIt synonyms : Lentivirus-transduced AML Blasts Expressing B7.1 and IL-2; LV IL-2 B7 1-Transduced AML Blast Vaccine;
NCIt definition : A whole-cell cancer vaccine, containing human acute myeloid leukemic (AML) blasts
that have been genetically engineered to express a B7.1/IIL-2 fusion protein encoded
by a self-inactivating lentiviral vector (LV), with potential antineoplastic and immunomodulating
activities. Upon administration, LV.IL-2/B7.1-transduced AML blast vaccine RFUSIN2-AML1
may stimulate a host cytotoxic T lymphocyte (CTL) response against AML cells. The
single fusion protein encoded by the LV is postsynthetically cleaved to produce biologically
active membrane-anchored B7.1 and secreted IL-2 in AML blasts; combined expression
of IL-2 and the co-stimulatory molecule B7.1 by AML blasts may increase stimulation
of both allogeneic and autologous cytotoxic T cells.;
Molecule name : RFUSIN2-AML1;
NCI Metathesaurus CUI : CL387720;
Origin ID : C78832;
UMLS CUI : C2697863;
Semantic type(s)
- concept_is_in_subset
