Preferred Label : Autologous OFA-iLRP RNA-Transfected Dendritic Cell Vaccine;
NCIt synonyms : OFA-iLRP-Loaded Autologous Dendritic Cell Vaccine;
NCIt definition : A cancer vaccine consisting of autologous, mature monocyte-derived dendritic cells
(DCs) transfected with oncofetal antigen immature laminin receptor protein (OFA-iLRP)
RNA, with potential antineoplastic activity. Upon administration, DCs in the OFA-iLRP
RNA-transfected autologous dendritic cell vaccine express, process, and present OFA-iLRP
to the host immune system, which may mount a potent cytotoxic T-cell (CTL) response
against OFA-iLRP-expressing tumor cells. As a highly conserved protein, OFA-iLRP is
preferentially expressed in fetal tissues and in many types of cancer, including hematopoietic
malignancies, but is not detectable in normal differentiated adult cells.;
NCI Metathesaurus CUI : CL387729;
Origin ID : C78830;
UMLS CUI : C2825153;
Semantic type(s)
- concept_is_in_subset
