Preferred Label : Anti-DR5 Agonist Monoclonal Antibody TRA-8;
NCIt synonyms : Anti-death Receptor 5 Agonist Monoclonal Antibody TRA-8;
NCIt definition : An agonist mouse monoclonal antibody directed against TRAIL death receptor type 5
(DR5) with potential antineoplastic activity. Anti-DR5 agonist monoclonal antibody
TRA-8 binds DR5, which may induce apoptosis in DR5-expressing tumor cells. DR5 is
a tumor cell surface ligand that crosslinks with death receptor type 4 (DR4) when
bound by TRAIL [Tumor necrosis (TNF)-related apoptosis-inducing ligand], triggering
apoptosis via a death receptor signaling pathway. The apoptotic activity of this antibody
may not require DR4/DR5 crosslinking.;
Molecule name : TRA-8;
NCI Metathesaurus CUI : CL387674;
Origin ID : C78826;
UMLS CUI : C2698135;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
