Idelalisib - CISMeF

Preferred Label : Idelalisib;

NCIt synonyms : Phosphoinositide-3 Kinase Delta Inhibitor CAL-101; 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H- quinazolin-4-one; PI3K-delta Inhibitor CAL-101;

NCIt definition : An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.;

UNII : YG57I8T5M0;

InChIKey : IFSDAJWBUCMOAH-HNNXBMFYSA-N;

CAS number : 870281-82-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 870281-82-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zydelig;

Molecule name : CAL-101; GS-1101; GS 1101;

Codes from synonyms : 267;

Details

Origin ID

C78825;

UMLS CUI

C2698692;

Automatic exact mappings (from CISMeF team)
- Idelalisib [ICD-11 More detail]
- idelalisib [ATC Code]
Currated CISMeF NLP mapping
- Idelalisib (substance) [SNOMED CT concept]
- idelalisib [International Nonproprietary Name]
- idelalisib [MeSH concept]
- idelalisib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing idelalisib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Idelalisib (substance) [SNOMED CT concept]
- Product containing idelalisib (medicinal product) [SNOMED CT concept]
- idelalisib [MeSH concept]
- idelalisib [MeSH Supplementary Concept]
- idelalisib [International Nonproprietary Name]
- idelalisib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
is_component_of_chemotherapy_regimen
- Bendamustine/Idelalisib/Rituximab Regimen [NCIt concept]
- Idelalisib Regimen [NCIt concept]
- Idelalisib/Rituximab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients