Pyrimethamine - CISMeF

Preferred Label : Pyrimethamine;

NCIt related terms : Daraprim;

NCIt definition : A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04);

UNII : Z3614QOX8W;

InChIKey : WKSAUQYGYAYLPV-UHFFFAOYSA-N;

CAS number : 58-14-0;

Drug name : Daraprim;

Chemical formula : C12H13ClN4;

NSC code : 3061;

ChEBI ID : CHEBI:8673;

Codes from synonyms : NSC0003061;

Details

Origin ID

C788;

UMLS CUI

C0034283;

See also inter- (CISMeF)
- Product containing pyrimethamine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing pyrimethamine (medicinal product) [SNOMED CT concept]
- Pyrimethamine [ICD-11 Extension code]
- Pyrimethamine [LOINC component]
- Pyrimethamine (substance) [SNOMED CT concept]
- pyrimethamine [ATC Code]
- pyrimethamine [Substance BNPC]
- pyrimethamine [MeSH Descriptor]
- pyrimethamine [MeSH concept]
- pyrimethamine [SNOMED Notion]
Validated automatic mappings to BTNT
- pyrimethamine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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