APL Differentiation Syndrome

Preferred Label : APL Differentiation Syndrome;

NCIt related terms : Retinoic Acid Syndrome; Differentiation Syndrome;

NCIt definition : A syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis, and renal failure.;

Alternative definition : NICHD: A disorder manifesting with fever, leukocytosis, hypotension, and possible cardiac and renal failure as a result of treatment with all-trans retinoic acid or arsenic trioxide.; CTCAE: A disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid.;

Codes from synonyms : E13554;

Details

Origin ID

C78597;

UMLS CUI

C0860564;

Automatic exact mappings (from CISMeF team)
- APL differentiation syndrome [MedDRA LLT]
- Differentiation syndrome [MedDRA Preferred Term]
- Differentiation syndrome due to and following chemotherapy co-occurrent with acute promyelocytic leukemia (disorder) [SNOMED CT concept]
- Retinoic acid syndrome [MedDRA LLT]
- Retinoic acid syndrome (disorder) [Inactive SNOMED CT concept]
- acute promyelocytic leukaemia differentiation syndrome [MedDRA Preferred Term]
Currated CISMeF NLP mapping
- retinoic acid syndrome [MedDRA Preferred Term]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Differentiation syndrome [MedDRA Preferred Term]
- Retinoic acid syndrome [MedDRA LLT]
- Retinoic acid syndrome (disorder) [Inactive SNOMED CT concept]
- retinoic acid syndrome [MedDRA Preferred Term]
concept_is_in_subset
- CTCAE Adverse Events Version 4.0 Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Adverse Events Terminology [NCIt concept]
- Pediatric Adverse Events Terminology Mapped to MedDRA [NCIt concept]

Keyword's position in hierarchy(ies) :

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