Preferred Label : White Button Mushroom Extract;
NCIt synonyms : WBM Extract;
NCIt definition : A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential
chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides
and especially beta-D-glucans found in the white button mushroom extract, bind to
and inhibit the activity of aromatase, an enzyme responsible for the conversion of
androgens to estrogens and which is often upregulated in breast cancer cells. The
consequent decrease in estrogen production may result in the suppression of estrogen-dependent
cellular proliferation. In addition, this extract may promote dendritic cell (DC)
maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha
(TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying
both innate and T cell-mediated immune responses against cancer cells.;
NCI Metathesaurus CUI : CL387508;
Origin ID : C78490;
UMLS CUI : C2700272;
Semantic type(s)
- concept_is_in_subset
