Preferred Label : Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells;
NCIt synonyms : KRN7000-Pulsed Autologous Dendritic Cells; DC-KRN7000; Alpha-Galactosyl Ceramide-Pulsed Autologous Dendritic Cells;
NCIt definition : A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine
sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory
and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed
autologous dendritic cells may result in the activation and proliferation of a subset
of endogenous natural killer T (NKT) cells, B cells, and CD4 and CD8 T cells, and
the production of interferon-gamma and interleukin-12; these cascade events may result
in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell
ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis.;
NCI Metathesaurus CUI : CL387518;
Origin ID : C78489;
UMLS CUI : C2698062;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
