Preferred Label : IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine;
NCIt synonyms : Interleukin-2/Lymphotactin Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine; IL-2/Lptn Loaded Allogeneic Neuroblastoma Cell Vaccine; SJNB-JF-IL2 and SJNB-JF-Lptn Cells and SKNLP Unmodified Neuroblastoma Cell Lines; Interleukin-2 Lymphotactin Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine;
NCIt definition : A cancer vaccine consisting of allogeneic neuroblastoma tumor cells have been genetically
modified to secrete the human cytokine interleukin-2 (IL-2) and the human chemokine
lymphotactin (Lptn) with potential immunostimulating and antineoplastic activities.
Upon administration, IL-2 and Lptn are secreted by the IL-2/Lptn gene-modified allogeneic
neuroblastoma tumor cell vaccine, potentially enhancing the cytotoxic T lymphocyte
(CTL) response elicited by vaccine neuroblastoma tumor-associated antigens (TAAs)
against host neuroblastoma tumor cells. Produced by activated progenitor T cells,
Lptn belongs to the C chemokine subfamily and is a potent chemotactic factor for lymphocytes;
IL-2 stimulates natural killer (NK) cells and may enhance a vaccine-elicited CTL immune
response against tumor cells.;
NCI Metathesaurus CUI : CL387477;
Origin ID : C78487;
UMLS CUI : C2697757;
Semantic type(s)
- concept_is_in_subset
