Anti-PLGF Monoclonal Antibody TB-403

Preferred Label : Anti-PLGF Monoclonal Antibody TB-403;

NCIt synonyms : Anti-Placental Growth Factor Monoclonal Antibody TB-403; Anti-PGF Monoclonal Antibody RO5323441;

NCIt related terms : TB-403;

NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the placenta growth factor (PGF), with potential anti-angiogenic and antineoplastic activities. Anti-PGF monoclonal antibody TB-403 binds to both PGF-1 and -2, thereby inhibiting the binding of PGF-1 and -2 to the vascular endothelial growth factor receptor-1 (VEGFR-1) and subsequent VEGFR-1 phosphorylation. This may result in the inhibition of tumor angiogenesis and tumor cell proliferation. PGF, a member of the VEGF sub-family and a key molecule in angiogenesis and vasculogenesis, is upregulated in many cancers.;

UNII : 46MVG4H2LF;

Molecule name : RG7334; TB-403; THR 317; RO5323441; THR-317;

NCI Metathesaurus CUI : CL387523;

Details

Origin ID

C78486;

UMLS CUI

C3490100;

Currated CISMeF NLP mapping
- TB-403 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TB-403 [MeSH Supplementary Concept]
- TB-403 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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