" /> Ombrabulin - CISMeF





Preferred Label : Ombrabulin;

NCIt synonyms : Combretastatin A4 Analogue AVE8062; (2S)-2-amino-3-hydroxy-n-(2-methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl)propanamide;

NCIt definition : A synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis.;

UNII : 82JB1524Q6;

InChIKey : IXWNTLSTOZFSCM-YVACAVLKSA-N;

CAS number : 181816-48-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 181816-48-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AC7700; AVE8062;

Chemical formula : C21H26N2O6;

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15/05/2024


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