NCIt definition : A cancer vaccine consisting of a recombinant form of human melanoma antigen A3 (MAGE-A3)
combined with a proprietary adjuvant with potential immunostimulatory and antineoplastic
activities. Upon administration, astuprotimut-R may stimulate a cytotoxic T lymphocyte
(CTL) response against tumor cells expressing the MAGE-A3 antigen, resulting in tumor
cell death. MAGE-A3, a tumor-associated antigen (TAA) originally discovered in melanoma
cells, is expressed by various tumor types. The proprietary immunostimulating adjuvant
in this agent is composed of a specific combination of immunostimulating compounds
selected to increase the anti-tumor immune response to MAGE-A3.;
UNII : 50I23C5UOR;
CAS number : 949885-73-8;
Molecule name : GSK1203486A; MAGE-A3; GSK1572932A;
Semantic type(s)