Preferred Label : Topical Betulinic Acid;
NCIt definition : A topical formulation of a pentacyclic lupane-type triterpene derivative of betulin
(isolated from the bark of Betula alba, the common white birch) with antiinflammatory,
anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction
of changes in mitochondrial membrane potential, production of reactive oxygen species,
and opening of mitochondrial permeability transition pores, resulting in the release
of mitochondrial factors involved in apoptosis, activation of caspases, and DNA fragmentation.
Although originally thought to exhibit specific cytotoxicity against melanoma cells,
this agent has been found to be cytotoxic against non-melanoma tumor cell types including
neuroectodermal and brain tumor cells.;
Molecule name : Topical ALS-357;
NCI Metathesaurus CUI : CL387585;
Origin ID : C78477;
UMLS CUI : C2699966;
Semantic type(s)
- concept_is_in_subset
