Preferred Label : Topical Myristyl Nicotinate Cream;
NCIt related terms : myristyl nicotinate cream;
NCIt definition : A topical cream containing the ester prodrug myristyl nicotinate (MN), a lipophilic
nicotinic acid derivative with potential chemopreventive activity. Upon topical application,
myristyl nicotinate penetrates into the epidermis where the agent is cleaved and is
converted into nicotinic acid (niacin); nicotinic acid then diffuses into cells where
it is converted to nicotinamide adenine dinucleotide (NAD). NAD may stimulate poly(ADP-ribose)
polymerase-1 (PARP-1); enhance skin cell turnover and epidermal differentiation; and
strengthen skin barrier function. NAD is a coenzyme that plays a crucial role in many
redox reactions; PARP-1 is an enzyme that plays an important role in DNA repair.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of skin cancer. Myristyl nicotinate
cream is also being studied as a way to help lessen the side effects of retinoic acid
(a form of vitamin A) when it is used to treat skin that has been damaged by the sun.
Myristyl nicotinate cream contains a form of niacin (a member of the vitamin B complex).
It is a type of chemopreventive agent.;
NCI Metathesaurus CUI : CL387586;
Codes from synonyms : CDR0000626298;
Origin ID : C78469;
UMLS CUI : C2699967;
Semantic type(s)
- concept_is_in_subset
