Preferred Label : Fluorine F-18 ML-10;
NCIt synonyms : Fluorine F18-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-Acid; [18F]-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-Acid; [18F]-ML-10; Fluorine F 18 ML-10; 18F 2 5-Fluoro-Pentyl 2-Methyl-Malonic Acid;
NCIt definition : A small molecular-weight, malonic acid-based probe [(2-(5-fluoro-pentyl)-2-methyl-malonic
acid or ML-10] labeled with the radioactive isotope fluorine F 18 with potential apoptosis
radioimaging use. Upon administration, [F18]-ML-10 binds selectively to apoptotic
cells due to apoptotic cell membrane features that differ from those of normal, healthy
and necrotic cell membranes. Upon entering the apoptotic cell, this agent accumulates
within the cytoplasm where it can be imaged using positron emission tomography (PET).
Detection of apoptotic cells using this imaging technology may be useful in monitoring
tumor responses to cytotoxic therapies. ML-10 appears to mimic the alkyl-malonic acid
motif present in gamma -carboxyglutamic (Gla), an amino acid that plays a crucial
role in the binding of clotting factors to negatively-charged phospholipids exposed
on the surfaces of apoptotic cells.;
Drug name : ApoSense ML-10;
NCI Metathesaurus CUI : CL387589;
Origin ID : C78468;
UMLS CUI : C2700345;
Semantic type(s)
- concept_is_in_subset
