Preferred Label : CMVpp65-A*0201 Peptide Vaccine;
NCIt synonyms : CMVpp65-A 0201 Peptide Vaccine;
NCIt definition : A peptide-based cancer vaccine containing a mutated form of the HLA-A*0201-restricted
cytomegaloviral epitope CMVpp65(495-503) with potential immunostimulatory and antitumor
activities. Upon subcutaneous administration, CMVpp65-A*0201 peptide vaccine may stimulate
a cytotoxic T lymphocyte (CTL) response against CMV-positive cells, resulting in cell
lysis. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8
T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201
may improve antigenic peptide immunogenicity. CMVpp65, a tegument protein of the herpes
virus CMV, is the main viral antigen found in peripheral blood mononuclear cells (PBMCs)
after viral infection and may activate cell-mediated immunity.;
NCI Metathesaurus CUI : CL387542;
Origin ID : C78467;
UMLS CUI : C2698732;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
