NCIt definition : Leakage of a pharmacologic or a biological substance from the infusion site into the
surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning
sensation, and pain at the infusion site.;
Alternative definition : CTCAE: A disorder characterized by leakage of a pharmacologic or a biologic substance
from the infusion site into the surrounding tissue. Signs and symptoms include induration,
erythema, swelling, burning sensation and marked discomfort at the infusion site.;