" /> IgG4 - CISMeF





Preferred Label : IgG4;

NCIt synonyms : Immunoglobulin G4; Immunoglobulin G Subclass 4;

NCIt definition : Along with the immunoglobulin G3 subclass (IgG3), the IgG4 subtype makes up a minor part of circulating antibodies in healthy individuals. The IgG4 core hinge sequence contains 12 amino acids and two interchain disulfide bonds.This subtype has moderate affinity for binding Fc receptors and does not bind complement component C1q. The production of IgG4 can be stimulated following repeated or long-term exposure to antigen. Elevated levels are found in various diseases and infections and can be indicative of an fibroinflammatory syndrome known as IgG4-related disease.;

PubMed : 25368619;

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31/07/2025


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