IgG4 - CISMeF

Preferred Label : IgG4;

NCIt synonyms : Immunoglobulin G4; Immunoglobulin G Subclass 4;

NCIt definition : Along with the immunoglobulin G3 subclass (IgG3), the IgG4 subtype makes up a minor part of circulating antibodies in healthy individuals. The IgG4 core hinge sequence contains 12 amino acids and two interchain disulfide bonds.This subtype has moderate affinity for binding Fc receptors and does not bind complement component C1q. The production of IgG4 can be stimulated following repeated or long-term exposure to antigen. Elevated levels are found in various diseases and infections and can be indicative of an fibroinflammatory syndrome known as IgG4-related disease.;

PubMed : 25368619;

Details

Origin ID

C78227;

UMLS CUI

C0020860;

Automatic exact mappings (from CISMeF team)
- IgG immunoglobulin complex [GO term]
- IgG subclass 4 [LOINC component]
- Immunoglobulin G4 related disease (disorder) [SNOMED CT concept]
- Immunoglobulin IgG4 (substance) [SNOMED CT concept]
- immunoglobulin G [MeSH Descriptor]
Currated CISMeF NLP mapping
- IgG4 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IgG subclass 4 [LOINC component]
- IgG4 [LOINC part]
- IgG4 [MeSH concept]
- Immunoglobulin IgG4 (substance) [SNOMED CT concept]
- immunoglobulin igg4 [SNOMED Notion]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Antibody [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
has_gene_product_element
- Immunoglobulin Heavy Constant Gamma 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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